Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2

Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation.

Staphylococcal protein A (SpA) is representative of a new class of antigens, the B-cell superantigens (SAgs). These antigens bind to the Fab regions of immunoglobulin molecules outside their complementarity-determining regions. SpA, the best-studied B-cell SAg, reacts with the Fabs of most VH3+ immunoglobulins, which are expressed on 30 to 60% of human peripheral B cells. Therefore, B-cell SAgs...

Role of lipocalin 2, an innate immune protein, during immune-complex mediated inflammation

L (Lcn2), an innate immune protein, predominantly secreted by neutrophils is upregulated by several logs during inflammatory conditions including autoimmune diseases. However, the defined role of Lcn2 in autoimmune diseases is largely unknown. We investigated the role of Lcn2 in an acute model of IC-mediated inflammation using Lcn2 knock out (Lcn2KO) and their wild type (WT) littermates. In an ...

Inflammatory and Immune-Mediated Cutaneous Diseases

Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation.

Necrotizing enterocolitis (NEC), an extensive intestinal inflammatory disease of premature infants, is caused, in part, by an excessive inflammatory response to initial bacterial colonization due to the immature expression of innate immune response genes. In a randomized placebo-controlled clinical trial, supplementation of very low birth weight infants with probiotics significantly reduced the...

The role of neutrophils in immune dysfunction during severe inflammation.

Critically ill post-surgical, post-trauma and/or septic patients are characterised by severe inflammation. This immune response consists of both a pro- and an anti-inflammatory component. The pro-inflammatory component contributes to (multiple) organ failure whereas occurrence of immune paralysis predisposes to infections. Strikingly, infectious complications arise in these patients despite the...